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Mannitol Spheres

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Mannitol Spheres

Segment : Neutral Spheres


Size : 100-200 μm, 200-355 μm, 350-500 μm, 500-710 μm, 700-1000 μm, 1000-1400 μm

Available Strength : 100%

Product Code : 01{confidential}

Featured Information On Mannitol Spheres

Mannitol is a water-soluble substitute for sugar sphere in drug layering. Mannitol spheres are cutting-edge particles with diverse applications in the pharmaceutical and biomedical fields. These mannitol spheres, composed primarily of mannitol, a naturally occurring sugar alcohol, offer a range of advantages for drug release systems.

Manufactured meticulously, mannitol spheres exhibit uniform size and a perfect spherical shape, ensuring consistency and reliability. Their exceptional properties make them ideal for controlled-release products, where drugs can be encapsulated within or adsorbed onto their porous surface. This mannitol enables targeted, maximizing therapeutic efficacy and minimizing potential side effects.

At Umang Global, as a manufacturer of mannitol sphere provide uniform drug layering, ideal for enteric coating and sustained release. These mannitol spheres also have low friability and high mechanical strength. Recognized for their biocompatibility and safety, they have undergone extensive evaluation. Their biocompatible nature ensures compatibility with the human body, minimizing the risk of adverse reactions or tissue damage.

Small spherical particles made from the sugar alcohol mannitol are known as mannitol spheres, mannitol microspheres, or microballoons. Drugs can be incorporated into the mannitol spheres and then released in a controlled manner as the spheres dissolve in the body. They are frequently used as drug delivery systems in the pharmaceutical industry.

In order to create mannitol spheres, a procedure known as spray drying is usually used. During this process, a solution containing mannitol and the target drug is atomized into a fine mist and then dried. The resulting particles have a porous structure that allows drugs to be loaded and released, and they typically range in size from 1 to 100 micrometres.

The use of mannitol spheres for drug delivery has several benefits. They can be safely metabolised by the body because they are biocompatible and biodegradable. Additionally, they can make drugs more soluble and prevent them from degrading, which will boost their bioavailability and efficiency.

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Benefits of Mannitol sphere

  • High abrasion resistance simplifies the coating process.
  • Mannitol spheres have low friability and high mechanical strength.
  • Mannitol spheres are used as bulking agents in food products.
  • Ideal for drug release and coating
  • Alternative to sugar spheres and controlled release products.
  • Allergen-free, Gluten-free
  • Residual solvent free
  • Mannitol spheres are odorless and pleasant, sweet taste.
  • Substitute of sugar sphere in drug layering

Reasons to use Mannitol sphere.

  • Ready for instant drug layering
  • Uniform drug layering
  • Perfect sphericity
  • Wide range of particle sizes to meet different dose levels.
  • Total Compliance with EP, USP, and IP.
  • Higher drug stability
  • Customized release profile
  • Reduced risk of sudden dose dumping

Regulatory Information of Mannitol sphere

  • CAS- No. 69-65-8
  • In compliance with EP, USP, IP
  • BSE/TSE free
  • Allergen free, Gluten free
  • Residual solvent free

Storage conditions for Mannitol sphere:

  • Protect from excessive temperature
  • Protect from moisture
  • Protect from freezing
  • Re-evaluation 36 months from date of manufacturing

General properties related to Neutral Spheres


  • Controlled drug delivery
  • Increased bioavailability
  • Biocompatibility and biodegradability
  • Targeted drug delivery
  • Versatility
  • Stability"


  • Controlled drug delivery
  • Targeted drug delivery
  • Imaging
  • Embolization
  • Tissue engineering
  • Cosmetics

Formats Available

  • Solid Mannitol spheres
  • Hollow Mannitol spheres
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